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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30161
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dc.contributor.authorDuggal, Niharika Aroraen_UK
dc.contributor.authorUpton, Janeen_UK
dc.contributor.authorPhillips, Anna Cen_UK
dc.contributor.authorHampson, Peteren_UK
dc.contributor.authorLord, Janet Men_UK
dc.date.accessioned2019-09-26T00:00:12Z-
dc.date.available2019-09-26T00:00:12Z-
dc.date.issued2015-02-07en_UK
dc.identifier.other11en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30161-
dc.description.abstractNK cell cytotoxicity (NKCC) reduces with age and this has been associated previously with increased mortality. The immune response is also modulated by stress, and here, we assessed the effect of the physical stress of hip fracture and the psychological stress of depression on NKCC in an aged immune system. NKCC was assessed in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and in 50 healthy age-matched controls (28 female). Thirty-eight patients were depressed at 6 weeks post-injury, and NKCC was reduced in patients who developed depression compared with non-depressed hip fracture patients (p = 0.004) or controls (p en_UK
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.relationDuggal NA, Upton J, Phillips AC, Hampson P & Lord JM (2015) NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. AGE, 37 (1), Art. No.: 11. https://doi.org/10.1007/s11357-015-9748-2en_UK
dc.rightsCopyright The Author(s) 2015. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectNK cellen_UK
dc.subjectStressen_UK
dc.subjectImmunesenescenceen_UK
dc.subjectCortisolen_UK
dc.titleNK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expressionen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1007/s11357-015-9748-2en_UK
dc.identifier.pmid25663421en_UK
dc.citation.jtitleAGEen_UK
dc.citation.issn1574-4647en_UK
dc.citation.issn0161-9152en_UK
dc.citation.volume37en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEconomic and Social Research Councilen_UK
dc.author.emaila.c.whittaker@stir.ac.uken_UK
dc.citation.date07/02/2015en_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.identifier.isiWOS:000349524600011en_UK
dc.identifier.scopusid2-s2.0-84923103720en_UK
dc.identifier.wtid1420376en_UK
dc.contributor.orcid0000-0002-5461-0598en_UK
dc.date.accepted2015-01-22en_UK
dcterms.dateAccepted2015-01-22en_UK
dc.date.filedepositdate2019-07-30en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorDuggal, Niharika Arora|en_UK
local.rioxx.authorUpton, Jane|en_UK
local.rioxx.authorPhillips, Anna C|0000-0002-5461-0598en_UK
local.rioxx.authorHampson, Peter|en_UK
local.rioxx.authorLord, Janet M|en_UK
local.rioxx.projectProject ID unknown|Economic and Social Research Council|http://dx.doi.org/10.13039/501100000269en_UK
local.rioxx.freetoreaddate2019-09-25en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2019-09-25|en_UK
local.rioxx.filenameHip dep NK cells.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1574-4647en_UK
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