Synthetic approaches to thromboxanes

Abstract

The more recent developments in the fields of prostaglandin and thromboxane chemistry, and biochemistry, are briefly discussed. The existing syntheses of thromboxane-B2 and analogues of thromboxane-A2 are comprehensively reviewed. Various synthetic approaches to, and the successful synthesis of, a key thromboxane-B2 synthon from a sugar precursor are presented. Some synthetic approaches to a novel thromboxane-A2 analogue are also discussed.