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dc.contributor.authorHall, Elliott C Ren_UK
dc.contributor.authorLockey, Sarah Jen_UK
dc.contributor.authorHeffernan, Shane Men_UK
dc.contributor.authorHerbert, Adam Jen_UK
dc.contributor.authorStebbings, Georgina Ken_UK
dc.contributor.authorDay, Stephen Hen_UK
dc.contributor.authorCollins, Malcolmen_UK
dc.contributor.authorPitsiladis, Yannis Pen_UK
dc.contributor.authorErskine, Robert Men_UK
dc.contributor.authorWilliams, Alun Gen_UK
dc.description.abstractSuccess in long-distance running relies on multiple factors including oxygen utilisation and lactate metabolism, and genetic associations with athlete status suggest elite competitors are heritably predisposed to superior performance. The Gly allele of the PPARGC1A Gly482Ser rs8192678 polymorphism has been associated with endurance athlete status and favourable aerobic training adaptations. However, the association of this polymorphism with performance amongst long-distance runners remains unclear. Accordingly, this study investigated whether rs8192678 was associated with elite status and competitive performance of long-distance runners. Genomic DNA from 656 Caucasian participants including 288 long-distance runners (201 men, 87 women) and 368 non-athletes (285 men, 83 women) was analysed. Medians of the 10 best UK times (Top10) for 10 km, half-marathon and marathon races were calculated, with all included athletes having personal best (PB) performances within 20% of Top10 (this study’s definition of “elite”). Genotype and allele frequencies were compared between athletes and non-athletes, and athlete PB compared between genotypes. There were no differences in genotype frequency between athletes and non-athletes, but athlete Ser allele carriers were 2.5% faster than Gly/Gly homozygotes (p = 0.030). This study demonstrates that performance differences between elite long-distance runners are associated with rs8192678 genotype, with the Ser allele appearing to enhance performance.en_UK
dc.publisherTaylor and Francisen_UK
dc.relationHall ECR, Lockey SJ, Heffernan SM, Herbert AJ, Stebbings GK, Day SH, Collins M, Pitsiladis YP, Erskine RM & Williams AG (2023) The PPARGC1A Gly482ser Polymorphism Is Associated with Elite Long-Distance Running Performance. <i>Journal of Sports Sciences</i>, 41 (1), pp. 56-62.
dc.rights© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. Share iconen_UK
dc.subjectEndurance runningen_UK
dc.subjectroad runningen_UK
dc.subjectpersonal besten_UK
dc.titleThe PPARGC1A Gly482ser Polymorphism Is Associated with Elite Long-Distance Running Performanceen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleJournal of Sports Sciencesen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderManchester Metropolitan Universityen_UK
dc.contributor.affiliationManchester Metropolitan Universityen_UK
dc.contributor.affiliationAnglia Ruskin Universityen_UK
dc.contributor.affiliationSwansea Universityen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationManchester Metropolitan Universityen_UK
dc.contributor.affiliationUniversity of Wolverhamptonen_UK
dc.contributor.affiliationUniversity of Cape Townen_UK
dc.contributor.affiliationUniversity of Brightonen_UK
dc.contributor.affiliationLiverpool John Moores Universityen_UK
dc.contributor.affiliationManchester Metropolitan Universityen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorHall, Elliott C R|en_UK
local.rioxx.authorLockey, Sarah J|en_UK
local.rioxx.authorHeffernan, Shane M|en_UK
local.rioxx.authorHerbert, Adam J|en_UK
local.rioxx.authorStebbings, Georgina K|en_UK
local.rioxx.authorDay, Stephen H|en_UK
local.rioxx.authorCollins, Malcolm|en_UK
local.rioxx.authorPitsiladis, Yannis P|en_UK
local.rioxx.authorErskine, Robert M|en_UK
local.rioxx.authorWilliams, Alun G|en_UK
local.rioxx.projectProject ID unknown|Manchester Metropolitan University|
local.rioxx.filenameThe PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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