STORRE
STORRE: Stirling Online Research Repository
http://hdl.handle.net/1893/38448| Appears in Collections: | Computing Science and Mathematics Journal Articles |
| Peer Review Status: | Refereed |
| Title: | The case for model-informed vaccine development |
| Author(s): | PF Bai, Jane Beigmohammadi, Fatemeh Craig, Morgan Dalton, Mackenzie Desikan, Rajat Easlick, Terry Gazeau, Sonia Heffernan, Jane Kirpichnikova, Anna Padmanabhan, Pranesh Sachs, Jeffrey R Sher, Anna Skibinski, David Smith, Amber M |
| Contact Email: | sam.dixon@stir.ac.uk |
| Keywords: | Model-informed vaccine development MIVD Quantitative systems pharmacology/toxicology QSP/T Mathematical models |
| Issue Date: | 24-Oct-2026 |
| Date Deposited: | 8-Oct-2026 |
| Citation: | PF Bai J, Beigmohammadi F, Craig M, Dalton M, Desikan R, Easlick T, Gazeau S, Heffernan J, Kirpichnikova A, Padmanabhan P, Sachs JR, Sher A, Skibinski D & Smith AM (2026) The case for model-informed vaccine development. <i>Vaccine</i>, 92, Art. No.: 128780. https://doi.org/10.1016/j.vaccine.2026.128780 |
| Abstract: | This perspective paper illustrates how model-informed vaccine development (MIVD) impacts vaccine discovery and development decisions, saving time and resources. It discusses the benefits of mechanistic and other mathematical models within MIVD. We outline key applications, opportunities, challenges, and future steps for MIVD as a call for the continued integration of mathematical modelling during vaccine development. |
| DOI Link: | 10.1016/j.vaccine.2026.128780 |
| Rights: | PF Bai, J., Beigmohammadi, F., Craig, M., Dalton, M., Desikan, R., Easlick, T., Gazeau, S., Heffernan, J., Kirpichnikova, A., Padmanabhan, P., Sachs, J. R., Sher, A., Skibinski, D., & Smith, A. M. (2026). The case for model-informed vaccine development. Vaccine, 92, 128780. DOI: https://doi.org/10.1016/j.vaccine.2026.128780 © 2026, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Licence URL(s): | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| File | Description | Size | Format | |
|---|---|---|---|---|
| MIVDPerspectiveR1_clean (1).docx | Fulltext - Accepted Version | 823.25 kB | Unknown | Under Embargo until 2027-09-22 Request a copy |
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